Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic and pharmacodynamic interactions between antiepileptics and antidepressants.
INTRODUCTION Antiepileptic-antidepressant combinations are frequently used by clinicians; their pharmacokinetic (PK) and pharmacodynamic (PD) drug interactions (DIs) have not been well studied but are frequently likely to be clinically relevant. AREAS COVERED This article provides a comprehensive review of PK DIs between antiepileptics and antidepressants. In the absence of PD DI studies, PD ...
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INTRODUCTION Pharmacokinetic and pharmacodynamic drug interactions (DIs) can occur between antiepileptics (AEDs) and second-generation antipsychotics (SGAPs). Some AED and SGAP pharmacodynamic mechanisms are poorly understood. AED-SGAP combinations are used for treating comorbid illnesses or increasing efficacy, particularly in bipolar disorder. AREAS COVERED This article provides a comprehen...
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BACKGROUND AND OBJECTIVE Dextromethorphan/quinidine (DMQ) is the first agent indicated for the treatment of pseudobulbar affect. Dextromethorphan, the active ingredient, is a low-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. This study evaluated the potential for a drug-drug interaction (DDI) of DMQ with memantine, which is also an NMDA receptor antagonist. METHODS ...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Metabolism & Toxicology
سال: 2014
ISSN: 1742-5255,1744-7607
DOI: 10.1517/17425255.2014.956081